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KMID : 0043319940170030170
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Archives of Pharmacal Research
1994 Volume.17 No. 3 p.170 ~ p.174
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Synthesis and Biological Activity of 6-Substituted-2-Oxo-Purine Nucleosides
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Lee Sang-Jun
Kim Jong-Bae
Cho Young-Ho
Kim Jung-Han
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Abstract
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We have synthesized various 6-substituted 2-oxo-purine nucleosides from key intemediate, 6-[(4-methylphenylthio)-2-oxo-9(2, 3, 5tri-o-acetyl--D-ribofuanoslyl)]-2, 3- dihydropurine in relatively high yields by one step nucleophilic substitution. Various isoguanosine, xanthosine analogs and other 2-oxo-purine nucleosides containing nitrogen, sulfur and oxygen at C-6 of purine base were easily obtained by this method. The structures of the products were established on the basis of their spectral data studies. And cytotoxicity of resulting synthetic 6-substituted-2-oxo-purine nucleosides against some tumor cell-lines was examined. values of these synthetic compounds were above except isoguanosine, -methyl isoguanosine and thioxanthosine analogs.
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KEYWORD
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6-Substituted-2-oxo-purine nucleosides, Nucleophilic subtitution, lsoguanosine analogs 6-[(4-methylphenythio)-2-oxo-9-(2, 3, 5, -tri-o-actyl-β-D-ribofuranosyl]-2, 3-dihydropurnie, Nucleophilic substitution
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